测定糖调节受损、2型糖尿病患者及正常人血浆obestatin水平。结果显示糖调节受损和2型糖尿病患者obestatin水平明显低于正常人,obestatin水平与体重指数、腰臀比、糖化血红蛋白、空腹胰岛素和稳态模型评估胰岛素抵抗指数呈负相关,提示obestatin可能参与代谢紊乱。 The levels of plasma obestatin were measured in patients with type 2 diabetes mellitus and normal subjects with impaired glucose regulation. The results showed that impaired glucose regulation and type 2 diabetes patients obestatin levels were significantly lower than normal, obestatin levels and body mass index, waist and hip ratio, glycosylated hemoglobin, fasting insulin and homeostasis model assessment of insulin resistance index was negatively correlated, suggesting that obestatin may be involved Metabolic disorders.