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肝转移是结直肠癌主要的转移模式及治疗关键。相对于全身化疗,肝动脉灌注(hepatic arterial infusion,HAI)给药方式可使肝脏局部药物浓度升高,而外周血液中药物浓度较低,全身不良反应相对较低。《中国肿瘤临床》于2015年第20期邀请中山大学肿瘤防治中心李宇红教授综述了肝动脉灌注化疗在结直肠癌肝转移的转化化疗、肝切除术后辅助治疗及结直肠癌根治性切除术后的肝转移预防方面的作用与价值。
Liver metastasis is the main mode of metastasis and treatment of colorectal cancer. Compared with systemic chemotherapy, hepatic arterial infusion (HAI) can increase the local drug concentration in the liver, lower the drug concentration in the peripheral blood and lower the systemic adverse reaction. China Academy of Oncology invites Sun Yat-sen University Cancer Center, Professor Li Yuhong, to summarize the therapeutic effect of hepatic arterial infusion chemotherapy in the conversion chemotherapy of liver metastasis of colorectal cancer, adjuvant hepatectomy and radical resection of colorectal cancer The role and value of liver metastasis prevention.