成人呼吸窘迫综合征简称ARDS 是继发于临床各科疾病如休克、创伤、败血症等以急性弥漫性肺损伤及肺动能障碍为特征的临床综合征.临床上以急性进行性呼吸困难、顽固性低氧血症为主要表现.病情危重,死亡率很高,约在50%以上,因此引起临床工作者的高度重视.本文仅对肺泡-毛细血管内皮损伤机制在ARDS 发病中的作用进行综述.一、历史回顾继发于创伤、休克,败血症等出现急性呼吸窘迫早在1936年Moon 就进行过描述,但直到1967年 ARDS is a clinical syndrome characterized by acute diffuse lung injury and pulmonary dysfunction secondary to various clinical diseases such as shock, trauma and sepsis. Clinically, acute progressive dyspnea, refractory Hypoxemia as the main manifestation of critically ill, high mortality rate, about 50% or more, it attracted great attention of clinicians.This paper reviews only the role of alveolar-capillary endothelial injury mechanism in the pathogenesis of ARDS. First, the historical review Secondary to trauma, shock, sepsis and other acute respiratory distress occurred as early as 1936 Moon described, but until 1967