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目的观察血必净对重症胸腹损伤患者创伤性凝血病的防治效果。方法将120例重症胸腹损伤患者随机分为观察组和对照组各60例。对照组采用常规对症治疗。观察组在对照组基础上加用血必净注射液治疗。对比2组治疗前后血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和内毒素(LPS),磷脂酶A2(PLA2)水平变化。对比2组凝血指标水平变化。结果治疗前2组血清TNF-α、IL-6、LPS、PLA2和PLT、APTT、PT水平水平差异无统计学意义(P>0.05)。治疗后2组血清TNF-α、IL-6、LPS、PLA2和APTT、PT均降低,PLT水平均升高,且观察组波动幅度大于对照组,差异均有统计学意义(P<0.05)。结论血必净注射液较好地控制了患者的炎性反应水平和内毒素水平,较好的维持了患者的凝血功能,明显起到防治重症胸腹损伤患者创伤后凝血病的发生,值得临床推广应用。
Objective To observe the effect of Xuebijing on traumatic coagulopathy in patients with severe thoracoabdominal injury. Methods 120 patients with severe chest and abdomen injury were randomly divided into observation group and control group of 60 cases. Control group using conventional symptomatic treatment. The observation group was added Xuebijing injection on the basis of the control group. The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and endotoxin (LPS) and phospholipase A2 (PLA2) in the two groups were compared before and after treatment. The changes of coagulation index in two groups were compared. Results There was no significant difference in serum levels of TNF-α, IL-6, LPS, PLA2 and PLT, APTT and PT before treatment (P> 0.05). After treatment, the levels of TNF-α, IL-6, LPS, PLA2, APTT and PT in the two groups decreased and the levels of PLT in the two groups increased. The fluctuation range of the observation group was larger than that of the control group (P <0.05). Conclusion Xuebijing Injection can better control the level of inflammatory reaction and endotoxin in patients, and better maintain the coagulation function of patients, which obviously plays a role in prevention and treatment of post-traumatic coagulopathy in patients with severe thoracoabdominal injuries. It is worth clinical Promote the application.