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目的观察小剂量(25μg)米索前列醇阴道后穹窿给药用于足月妊娠引产的有效性及安全性。方法选择有引产指征的孕足月、单胎头位、无宫缩、无引产禁忌证的孕妇88例,随机分为观察组和对照组每组44例。对照组采用缩宫素进行引产,观察组采用小剂量(25μg)米索前列醇进行引产,观察2组引产效果、用药至引产时间及产后出血量。结果观察组总有效率为86.4%高于对照组的59.1%,用药至临产时间短于对照组,产后出血量明显少于对照组,差异均有统计学意义(P<0.05)。结论小剂量米索前列醇于阴道后穹窿给药在足月妊娠引产中效果明显,不良反应少,安全性高,值得临床推广应用。
Objective To observe the effectiveness and safety of small dose (25 μg) misoprostol for vaginal fornix administration in term pregnancy induced labor. Methods Eighty-eight pregnant women with gestational age, single head position, no contractions and no contraindications of induction of labor were randomly divided into observation group and control group with 44 cases in each group. In the control group, oxytocin was used for induction of labor. The observation group was induced with a small dose (25 μg) of misoprostol. The effects of induction of labor, medication to induction of labor, and postpartum hemorrhage were observed. Results The total effective rate was 86.4% in the observation group and 59.1% in the control group. The duration of labor to delivery was shorter than that of the control group, and the amount of postpartum hemorrhage was significantly less than that of the control group. The differences were statistically significant (P <0.05). Conclusion Small doses of misoprostol in the vaginal fornix administration in term pregnancy induction effect is obvious, less adverse reactions, high safety, it is worth promoting the clinical application.