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目的:探讨恙虫病患者血清中降钙素原水平,并探讨血清降钙素(PCT)与恙虫病预后的关系。方法:本研究收集信宜市人民医院2013年7月到2015年7月恙虫病患者72例作为观察组,选择72例健康者作为对照组,两组人员在年龄等方面无差异。采用回顾性调查研究,前瞻性设计,用半定量的固相免疫测定法测定其血清内PCT水平并进行统计学分析;对观察组进行跟踪调查,观察其预后与血清内PCT水平的关系。结果:观察组患者血清中PCT水平明显高于对照组,恙虫病患者血清PCT阳性率90.28%,健康者全部为阴性,两组差异有统计学意义(χ~2=118.481,P=0.014);血清PCT水平与恙虫病预后呈显著正相关(r=0.883,P=0.023)。结论:血清内PCT水平可以作为恙虫病的一项敏感指标,同时对恙虫病的鉴别诊断、治疗及预后具有一定指导意义。
Objective: To investigate the serum procalcitonin levels in patients with scrub typhus and to investigate the relationship between serum calcitonin (PCT) and the prognosis of scrub typhus. Methods: 72 cases of tsutsugamushi disease were collected from Xinyi Municipal People’s Hospital from July 2013 to July 2015. 72 healthy subjects were selected as the control group. There was no difference in age between the two groups. Using retrospective investigation and prospective design, the level of PCT in serum was measured by semi-quantitative solid phase immunoassay and statistical analysis was performed. The observation group was followed up and the relationship between prognosis and serum PCT level was observed. Results: The serum PCT level in the observation group was significantly higher than that in the control group. The positive rate of PCT in the patients with tsutsugamushi disease was 90.28%, and all the healthy patients were negative. The difference was statistically significant (χ ~ 2 = 118.481, P = 0.014). Serum PCT levels were positively correlated with the prognosis of tsutsugamushi disease (r = 0.883, P = 0.023). CONCLUSION: The level of PCT in serum can be used as a sensitive index for scrub typhus, which is of guiding significance in the differential diagnosis, treatment and prognosis of scrub typhus.