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目的评价三磷酸胞苷二钠(CTP)治疗糖尿病周围神经病变(DPN)的疗效。方法100例DPN患者随机分为治疗组60例,对照组40例。均常规口服二甲双胍、格列吡嗪或联用胰岛素,使空腹血糖及餐后2h血糖控制理想,并均肌肉注射维生素B1100 mg、维生素B12500μg,每日1次,2周为1疗程,共用2疗程。治疗组在此基础上再加用CTP 60 mg,溶于250 ml生理盐水中静脉滴注,每日1次,2周为1疗程,共用2个疗程。结果治疗组疼痛、麻木、感觉异常等症状改善,总有效率88.3%,明显高于对照组的47.5%(P<0.01),神经传导速度的提高也明显优于对照组(P<0.01)。结论CTP联合维生素B1、B12治疗DPN效果良好。
Objective To evaluate the efficacy of disodium cytidine triphosphate (CTP) in the treatment of diabetic peripheral neuropathy (DPN). Methods One hundred patients with DPN were randomly divided into treatment group (60 cases) and control group (40 cases). Both conventional oral metformin, glipizide or combined with insulin, fasting blood glucose and 2h postprandial blood glucose control ideal, and intramuscular injection of vitamin B1100 mg, vitamin B12500μg, 1 day, 2 weeks for a course of treatment, a total of 2 courses . On the basis of the treatment group, CTP 60 mg was added to the treatment group, dissolved in 250 ml of normal saline intravenously once daily for 2 weeks for 1 course of treatment for 2 courses. Results The pain, numbness and sensory abnormalities in the treatment group were improved. The total effective rate was 88.3%, which was significantly higher than that in the control group (47.5%, P <0.01). The nerve conduction velocity was also significantly improved (P <0.01). Conclusion CTP combined with vitamin B1, B12 treatment of DPN good effect.