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目的:探讨孕中期产前筛查对胎儿染色体异常及神经管缺陷的价值。方法:对孕中期孕妇血清进行甲胎蛋白、游离绒毛膜促性腺激素β-亚基及游离雌三醇3项指标检测,用专用分析软件计算其风险率,并与B超、羊水、新生儿检查结果对照。结果:高风险孕妇检出率为4.88%,其中21三体综合征(DS)为2.74%,18三体综合征为0.48%,神经管畸形(NTD)为1.43%,其他胎儿异常为0.24%。结论:进行血清甲胎蛋白(AFP)、游离绒毛膜促性腺激素β-亚基(Free-βHCG)及游离雌三醇联合检测,有效降低了先天缺陷儿的出生率,可作为孕中期产前筛查优选项目。
Objective: To investigate the value of prenatal screening in the second trimester on fetal chromosomal abnormalities and neural tube defects. Methods: The serum of pregnant women in the second trimester was tested for the three indexes of alpha-fetoprotein, free chorionic gonadotrophin beta-subunit and free estriol. The risk was calculated by special analysis software, and combined with B-ultrasound, amniotic fluid, newborn Check the results of the control. Results: The detection rate of high risk pregnant women was 4.88%, of which 21 cases were trisomy 21 (DS), 0.48% for trisomy 18, 1.43% for NTD and 0.24% for other fetuses. . Conclusion: The combination of serum AFP, Free-βHCG and free estriol can effectively reduce the birth rate of children with congenital defects and can be used as the second trimester prenatal screening Check the preferred project.