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亲肝毒物进入机体后在肝脏内贮留和转化,可引起肝脏损害,肝脏实质细胞发生脂变、水样变性、坏死及纤维化。一般认为肝细胞的脂肪堆积和坏死是中毒性肝损害的生物化学基础,因此研究肝细胞损害的特点和组织化学、生物化学的改变是研究中毒性肝损害机理的基础。我们对四种亲肝毒物——四氯化
Pro-hepatotoxic agents into the body after storage and conversion in the liver, can cause liver damage, liver parenchymal cells fat, watery degeneration, necrosis and fibrosis. It is generally believed that hepatocyte fat accumulation and necrosis are the biochemical basis of toxic liver damage. Therefore, studying the characteristics of liver cell damage and histochemical and biochemical changes is the basis for studying the mechanism of toxic liver damage. We are four kinds of pro-liver poison - tetrachloride