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目的探讨血清中PCT和中性粒细胞CD64比例对小儿败血症患者的诊断及预后的评价价值。方法收集2015年9月-2016年9月确诊为败血症的患儿58例为观察组,分为细菌培养阳性组(37例)和细菌培养阴性组(21例);另选择无感染患儿37例为对照组,探讨患者血清中PCT和中性粒细胞CD64水平对小儿败血症的诊断价值及对患者预后的诊断价值。结果血培养阳性组患儿CD64、PCT均高于血培养阴性组和对照组,差异有统计学意义(P<0.05)。PCT+CD64联合的诊断效能较高,诊断的灵敏度、特异度、阳性预测值、阴性预测值均高于单独PCT和CD64进行败血症的诊断效能。PCT、CD64是患者心血管事件的独立风险因素(P<0.05)。结论血清中PCT和中性粒细胞CD64水平有助于小儿败血症的诊断,有助于判断患者预后。
Objective To investigate the value of serum PCT and neutrophil CD64 in the diagnosis and prognosis of children with sepsis. Methods Fifty-eight children diagnosed as sepsis from September 2015 to September 2016 were selected as the observation group and divided into bacterial culture positive group (n = 37) and bacterial culture negative group (n = 21) Cases as a control group to explore the serum PCT and neutrophil CD64 levels in children with sepsis diagnostic value and prognosis of patients with diagnostic value. Results The levels of CD64 and PCT in blood culture positive group were higher than those in negative blood culture group and control group (P <0.05). The diagnostic efficiency of PCT + CD64 combination was higher, and the diagnostic sensitivity, specificity, positive predictive value and negative predictive value were higher than those of PCT and CD64 alone. PCT, CD64 were independent risk factors for cardiovascular events in patients (P <0.05). Conclusion Serum PCT and neutrophil CD64 levels contribute to the diagnosis of pediatric sepsis and help to determine the prognosis of patients.