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目的探讨粒细胞肉瘤(GS)患者的临床特点、治疗方法和预后。方法回顾性分析57例GS患者的临床特点、治疗方法,并进行随访。结果 GS临床表现高度异质性,易发部位为软组织、中枢神经系统、淋巴结、胃肠道、乳腺等,表现为肿块占位症状及受累组织器官的功能障碍。单纯化疗组、单纯放疗组、放化疗联合组及未治疗组中位生存期分别为16个月、8个月、12个月及5个月,3 a生存率分别为14.3%、0.0%、11.1%及0.0%,单纯化疗组与单纯放疗组比较差异有统计学意义(P<0.001);单纯化疗组与放化疗联合组比较差异无统计学意义(P=0.527),4组均明显低于文献报道的行造血干细胞移植的治疗效果。结论 GS应接受标准急性髓系白血病化疗方案化疗,有条件者应尽早行造血干细胞移植。
Objective To investigate the clinical features, treatment and prognosis of patients with granulocystic sarcoma (GS). Methods Retrospective analysis of 57 cases of GS clinical features, treatment, and follow-up. Results The clinical manifestations of GS were highly heterogeneous. The sites of soft tissue, central nervous system, lymph nodes, gastrointestinal tract and mammary gland were the most likely sites for clinical manifestations of GS. The symptoms of tumor mass and the dysfunction of tissues and organs involved were observed. The median survival time was 16 months, 8 months, 12 months and 5 months in the chemotherapy alone group, the radiotherapy alone group, the radiotherapy and chemotherapy combination group and the untreated group, respectively. The 3-year survival rates were 14.3%, 0.0% 11.1% and 0.0% respectively. The difference between chemotherapy group and radiotherapy alone group was statistically significant (P <0.001). There was no significant difference between chemotherapy group and radiotherapy and chemotherapy group (P = 0.527) In the literature reported hematopoietic stem cell transplantation for the treatment effect. Conclusion GS should be treated with standard chemotherapy of acute myeloid leukemia chemotherapy, patients with conditions should be as soon as possible hematopoietic stem cell transplantation.