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丙型肝炎病毒引起慢性肝脏疾病的主要原因之一,HCV疫苗一直是研究的热点。多表位疫苗是指通过筛选与组合优势抗原表位(包括T细胞、B细胞表位)的新型核酸疫苗,目的在于产生高效的细胞免疫和体液免疫应答进而清除病毒。其优势在于通过选择最具免疫保护潜力的表位以覆盖尽量多的病毒亚型和诱导机体全面的抗病毒免疫应答。现就近年来国内外在丙型肝炎病毒多表位疫苗的研究做一介绍。
Hepatitis C virus is one of the main causes of chronic liver disease. HCV vaccine has been the hot spot of research. Multi-epitope vaccine refers to a new type of nucleic acid vaccine by screening and combining the dominant epitopes (including T cells, B cell epitopes), the purpose is to produce efficient cellular and humoral immune response and then clear the virus. This has the advantage of covering as many viral subtypes as possible by inducing the most immunogenic potential epitopes and in inducing the body’s overall antiviral immune response. Now in recent years at home and abroad in the hepatitis C virus multi-epitope vaccine to make an introduction.