目的探讨腹腔镜保留幽门保留脾的全胰切除术的可行性与安全性。方法回顾性分析1例实施腹腔镜下全胰切除术患者的临床资料及术后随访资料,对相关文献进行总结。结果患者因腹痛15年入院,CT检查考虑胰腺导管内乳头状瘤、慢性胰腺炎,行腹腔镜保留幽门保留脾的全胰切除术,病理结果为胰腺导管内乳头状黏液肿瘤,术后给予胰岛素降低血糖、胰酶促消化,术后23 d出院。结论腹腔镜保留幽门保留脾的全胰切除术是安全的、可行的。 Objective To investigate the feasibility and safety of total pancreatectomy for preserving the spleen by laparoscopy. Methods The clinical data and postoperative follow-up data of 1 patient who underwent total laparoscopic total pancreatectomy were retrospectively analyzed. The related literatures were summarized. Results The patients were admitted to hospital for 15 years because of abdominal pain. CT examination considered pancreatic ductal papilloma, chronic pancreatitis, laparoscopic pylorus-preserving splenic total pancreatectomy. The pathological result was intraductal papillary mucinous neoplasm. Postoperative insulin Reduce blood sugar, trypsin digestion, discharged after 23 days. Conclusion Laparoscopic preservation of pylorus-preserved pancreatectomy is safe and feasible.