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目的:探讨慢性充血性心力衰竭(CHF)病人应用沙度胺,治疗前后血浆心衰相关细胞因子水平及左室收缩功能变化。方法:将98例CHF病人(左室射血分数LVEF≤40％)随机分为2组,对照组常规应用治疗心衰药物,沙利度胺组在此基础上加用沙利度胺25～150mg·d-1,共用12wk,于治疗前后分别测定TNF-α,IL-6,超声心动图评价左室收缩功能。结果:CHF病人经沙利度胺治疗12wk后, TNF-α(p<0.01)、IL-6(P<0.05)水平均降低,且左室收缩功能显著改善(P<0.01)。结论:常规治疗慢性充血性心力衰竭基础上加用沙利度胺,安全易耐受,可显著改善CHF相关的临床症状和心功能。
Objective: To investigate the plasma level of TNF-α and left ventricular systolic function in patients with chronic congestive heart failure (CHF) before and after treatment with sand amine. Methods: 98 cases of CHF patients (LVEF ≤ 40%) were randomly divided into two groups. The control group was given routine treatment of heart failure drugs. Thalidomide group was treated with thalidomide 25 ~ 150mg · d-1, a total of 12wk, before and after treatment were measured TNF-α, IL-6, echocardiography evaluation of left ventricular systolic function. Results: After treated with thalidomide for 12 weeks, the levels of TNF-α (P <0.01) and IL-6 (P <0.05) decreased and the left ventricular systolic function improved significantly in CHF patients (P <0.01). Conclusion: The conventional treatment of chronic congestive heart failure based on the use of thalidomide, safe and easy to tolerate, can significantly improve the clinical symptoms associated with CHF and cardiac function.