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目的研究胸水中Survivin含量测定对肺癌性胸腔积液诊断的临床意义。方法收集102例经病理确诊的肺癌伴胸腔积液患者的胸水作为肿瘤组,以87例结核性渗出性胸膜炎患者的胸水为结核组。以ELISA法检测2组胸水中的Survivin含量,同时检测胸水中CEA、NSE、CYFRA21-1的含量并对结果进行统计学分析。结果肿瘤组胸水Survivin的含量为(52.290±41.421)pg/mL,与结核组胸水Survivin的含量(17.286±16.734)pg/mL相比明显升高,差异有统计学意义(P<0.01),其敏感性高于胸水CEA、NSE、CYFRA21-1等肿瘤标志物的检测。结论胸水中Survivin检测可作为肺癌所致胸腔积液诊断的一个敏感指标,具有一定临床实用价值。
Objective To study the clinical significance of the determination of Survivin in pleural effusion for the diagnosis of lung cancer pleural effusion. Methods Totally 102 pleural effusions of patients with lung cancer and pleural effusion diagnosed by pathology were collected as the tumor group. Pleural fluid of 87 patients with tuberculous exudative pleurisy was used as the tuberculosis group. The Survivin levels in two groups of pleural effusion were detected by ELISA, the contents of CEA, NSE and CYFRA21-1 in pleural effusion were measured simultaneously and the results were statistically analyzed. Results The level of Survivin in tumor pleural effusion was (52.290 ± 41.421) pg / mL, which was significantly higher than that in tuberculous pleural effusion (17.286 ± 16.734 pg / mL, P <0.01) Sensitivity than pleural effusion CEA, NSE, CYFRA21-1 and other tumor markers detection. Conclusion The detection of Survivin in pleural effusion can be used as a sensitive indicator in the diagnosis of pleural effusion caused by lung cancer and has certain clinical practical value.