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目的:观察贝前列素钠对老年2型糖尿病合并下肢血管病变患者的临床疗效及血清肿瘤坏死因子-α(TNF-α)、可溶性细胞间粘附分子-1(sICAM-1)的影响。方法:选择老年2型糖尿病合并下肢血管病变患者160例,分为对照组(80例)和观察组(80例)。两组均给予常规药物控制血糖。对照组:阿司匹林肠溶片75mg,口服,qd。观察组:贝前列素钠,40μg,口服,tid。6个月后观察疗效,采用ELISA法检测治疗前后血清TNF-α、sICAM-1。结果:观察组总有效率高于对照组(P<0.05);对照组治疗前后血清TNF-α、sICAM-1无明显变化(P>0.05);而观察组治疗后血清TNF-α、sICAM-1均明显低于治疗前及对照组治疗后水平(P<0.05)。结论:贝前列素钠对老年2型糖尿病合并下肢血管病变有较好疗效,能明显降低血清TNF-α、sICAM-1的表达。
Objective: To observe the effect of beraprost sodium on the clinical efficacy and the level of serum tumor necrosis factor-α (TNF-α) and soluble intercellular adhesion molecule-1 (sICAM-1) in elderly patients with type 2 diabetes mellitus complicated with lower extremity vascular disease. Methods: A total of 160 elderly patients with type 2 diabetes mellitus and lower extremity vascular disease were selected and divided into control group (80 cases) and observation group (80 cases). Both groups were given conventional drugs to control blood sugar. Control group: aspirin enteric-coated tablets 75mg, orally, qd. Observation group: beraprost sodium, 40μg, orally, tid. After 6 months, the curative effect was observed. The levels of serum TNF-α and sICAM-1 were measured by ELISA before and after treatment. Results: The total effective rate in the observation group was higher than that in the control group (P <0.05), while the levels of TNF-α and sICAM-1 in the control group had no significant changes before and after treatment (P> 0.05) 1 were significantly lower than before treatment and control group after treatment (P <0.05). Conclusion: Beraprost sodium has good effect on senile type 2 diabetes mellitus with lower extremity vascular lesions, and can significantly reduce the expression of serum TNF-α and sICAM-1.