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目的探讨孕妇肥胖对婴儿体格发育和瘦素质量浓度的影响。方法武汉大学人民医院儿科于2002年1月至2003年6月选择肥胖孕妇和正常体重孕妇各80例,比较她们的子代在出生后及满1岁时的体重、身高和血清瘦素质量浓度;瘦素检测使用双抗体夹心ELISA法。结果符合检测数据统计条件的肥胖组为53例,正常组49例。(1)肥胖孕妇的瘦素质量浓度明显高于正常体重孕妇(P<0·01);(2)肥胖孕妇组子代出生体重和脐血瘦素质量浓度明显高于正常组(P<0·01);(3)肥胖孕妇组子代1岁时体重和血清瘦素质量浓度明显高于正常组子代(P<0·05)。结论孕妇肥胖对婴儿的体重和瘦素质量浓度有明显的影响,此影响对子代以后的生长发育和瘦素质量浓度是否继续存在还需要进一步的研究。
Objective To investigate the effects of obesity on physical development and leptin concentration in infants. Methods The pediatric department of Wuhan University People’s Hospital selected obese pregnant women and normal pregnant women of 80 cases from January 2002 to June 2003. The weight, height and serum leptin concentration of their offsprings after birth and one year old were compared ; Leptin detection using double antibody sandwich ELISA method. Results According to the statistic conditions of the test data, 53 cases were obese and 49 cases were normal. (1) The leptin concentration in obese pregnant women was significantly higher than that in normal pregnant women (P <0.01). (2) The birth weight and umbilical cord blood leptin concentrations in obese pregnant women were significantly higher than those in normal pregnant women · 01). (3) The body weight and serum leptin level of obese pregnant women were obviously higher than those of the normal group (P <0.05). Conclusion The obesity of pregnant women has a significant effect on the body weight and leptin concentration of infants. Whether the effect of growth and development and the concentration of leptin in the offspring still need to be further studied.