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本文作者在非洲西部塞拉里昂进行随机双盲伊维菌素与安慰剂对照试验,探讨了伊维菌素低水平覆盖率对盘尾丝虫病传播的影响。 试验于1987年11月开始,在塞拉里昂Bo区Tabe河沿岸的6个村庄中给1745名居民服用伊维菌素或安慰剂,每6个月服一次,共服5次。在上述伊维菌素治疗村中选择4个点(相当于4个村),并在居民未治疗的村庄附近选1个对照点,自1987年9月至
The authors conducted a randomized double-blind ivermectin-placebo trial in Sierra Leone, western Africa, to examine the effects of low levels of ivermectin on the transmission of onchocerciasis. The trial began in November 1987 with 1,745 inhabitants taking ivermectin or placebo in six villages along the Tabe river in Boola area, Sierra Leone, taking it every five months for a total of five servings. Select 4 points (equivalent to 4 villages) in the above-mentioned ivermectin-treated villages and select 1 control point near the untreated villages. From September 1987 to