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目的研究艰难梭菌感染患者的临床特征,为临床对此类感染患者的诊断及治疗提供依据。方法回顾性分析感染性腹泻患者的艰难梭菌分离情况以及临床感染特点。结果从291份感染性腹泻标本中分离出33株艰难梭菌,阳性率为10.3%(18/174),其中26株为产A/B毒素菌株(12例患者)。艰难梭菌主要分离自老年男性,均具有严重基础疾病,且使用过质子泵抑制剂和多种广谱抗菌药物;粪便常规和血液学相关指标对艰难梭菌感染及产毒与否具有一定的指示作用。结论严重的艰难梭菌感染患者病死率高,且易引起院内感染的播散,医院可以根据此类患者的临床特征进行规范干预,从而有效地控制院内感染的爆发。
Objective To study the clinical characteristics of Clostridium difficile infection in patients with clinical diagnosis and treatment of these infections provide the basis. Methods The isolation of C. difficile in patients with infectious diarrhea and the characteristics of clinical infection were retrospectively analyzed. Results 33 Clostridium difficile isolates were isolated from 291 infectious diarrhea samples, with a positive rate of 10.3% (18/174), of which 26 were A / B toxin producing strains (12 patients). Clostridium difficile is mainly isolated from the elderly men, both with severe underlying diseases, and the use of proton pump inhibitors and a variety of broad-spectrum antimicrobial drugs; stool routine and hematology-related indicators of C. difficile infection and toxin production or not have a certain Indicate the role. Conclusion Severe C. difficile infection has a high case fatality rate and can easily lead to the spread of nosocomial infections. The hospital can regulate the patients according to their clinical characteristics so as to effectively control the outbreak of nosocomial infections.