局麻药是口腔科使用最多的一种药物,副作用是术后从刺入点中心部位的组织上发生溃疡及坏死,临床上这类病例很多。对于这个问题,有人报告,用大白鼠作实验动物进行了很多基础研究,结果表明:目前临床上所用的局部麻醉剂对骨胳肌是有毒的,其毒性还因添加肾上腺素后显著增大。最近Yagiela等作试验发现将2%的利多卡因中添加具有肾上腺素作用的药物,导致大白鼠大腿薄肌的损伤,他们还对其组织学方面进行了研究,同时还进行了对损伤的定量试验。他们还使用了C~(14)利多卡因,对导致注射部位残留少许的利多卡因,结果有类似肾上腺素的作用也 Local anesthetics are the most widely used drugs in dentistry. The side effects are ulceration and necrosis of tissues from the center of the puncturing point after operation, and many such cases are clinically seen. For this issue, it has been reported that many basic studies have been conducted in rats using animals as experimental animals. The results show that the local anesthetics currently used clinically are toxic to skeletal muscle and their toxicity is significantly increased by the addition of epinephrine. Recently Yagiela and other tests found that 2% of lidocaine to add adrenaline drugs, leading to damage in rats thigh thin muscle, they also conducted a study of its histology, but also for quantitative damage test. They also used C ~ (14) lidocaine, which caused a small amount of lidocaine in the injection site, resulting in a similar adrenaline effect