Martin等报道α-(二丁氨甲基)-6,8-二氯-2-(3,4-二氯苯基)-4-喹啉甲醇(WR 30090)对抗药性恶性疟疗效较高,光敏副作用小;这类化合物中的喹啉核用吡啶、菲、芴等其它芳环核取代所合成的化合物都具有一定的抗疟作用,α-(烷氨甲基)-2,7-二氯-4-芴甲醇就是一例。因此,作者等用喹唑啉核取代喹啉核合成了通式为I的化合物14个,I_(a～n)(表1),以期找到更有效的抗疟药。 Martin et al. Reported that the effect of a- (dibutylaminomethyl) -6,8-dichloro-2- (3,4-dichlorophenyl) -4- quinolinemethanol (WR 30090) Photosynthetic side effects; these compounds quinoline nucleus with pyridine, phenanthrene, fluorene and other aromatic ring nucleus substituted compounds synthesized have a certain anti-malarial effect, α- (alkylaminomethyl) -2,7-bis Chloro-4-fluorene methanol is an example. Therefore, the authors used quinazoline nuclear instead of quinoline nucleoside synthesis of compounds of formula I 14, I_ (a ~ n) (Table 1), in order to find more effective antimalarial drug.