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目的 :探讨急性冠状动脉综合征 (ACS)患者血清新蝶呤浓度的变化。方法 :对 4 7例ACS患者 ,其中急性心肌梗死 (AMI) 2 4例 ,不稳定型心绞痛 (UAP) 2 3例和 30例稳定型心绞痛 (SAP)患者 ,以酶联免疫法测定其血清新蝶呤水平 ,所有患者均为接受冠状动脉造影。结果 :血清新蝶呤浓度 ,在ACS病人中 ,AMI组 (1 1 88±3 0 9)nmol/L和UAP组 (9 85± 2 2 7)nmol/L ,均显著高于稳定型心绞痛患者的水平 (8 2 0± 1 5 2 )nmol/L ,(P <0 .0 0 0 1 ,P <0 .0 1 )同为ACS病人 ,AMI组与UAP之间其血清新蝶呤水平有显著差异 (P <0 .0 5 )。ACS的血清新喋呤水平与其不稳定斑块病变的数量有明显相关性。结果 :ACS病人血清新蝶呤浓度显著升高 ,可作为不稳定性动脉粥样硬化斑块的炎性标志
Objective: To investigate the change of serum neopterin in patients with acute coronary syndrome (ACS). Methods: Serum samples of 47 patients with acute myocardial infarction (AMI), 24 with acute myocardial infarction (AMI), 23 with unstable angina pectoris (UAP) and 30 with stable angina pectoris (SAP) The level of pterin, all patients underwent coronary angiography. Results: Serum neopterin concentration was significantly higher in AMI patients (1188 ± 399 nmol / L) and UAP group (9 85 ± 227) nmol / L than in patients with stable angina (8 20 ± 1 52) nmol / L, (P <0 0 01, P <0 01) were the same as ACS patients. The level of serum neopterin between AMI group and UAP was Significant difference (P <0. 05). Serum neopterin levels in ACS are significantly correlated with the number of unstable plaque lesions. Results: Serum neopterin concentration was significantly elevated in patients with ACS and could be used as an inflammatory marker of unstable atherosclerotic plaques