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目的 :探讨 PCNA和 EGFR在肺鳞癌、腺癌中的表达及与癌组织分型、淋巴结转移等方面的关系。方法 :用免疫组化 S- P法分别对 44例分化相近肺癌组织、1 6例正常肺组织 PCNA和EGFR的表达进行检测。结果 :肺癌组织 PCNA和 EGFR的表达明显高于正常肺组织。鳞癌与腺癌比较 ,PCNA和 EGFR表达无统计学差别 ( P>0 .0 5)。淋巴结转移阳性癌组织 PCNA和 EGFR表达与淋巴结转移阴性癌组织比较 ,无统计学差别 ( P>0 .0 5)。结论 :PCNA和 EGFR参与了肺癌的发生发展 ,在肺癌中表达有一定相关性。二者与鳞癌、腺癌分型无关 ,与淋巴结转移与否无关。
Objective: To investigate the expression of PCNA and EGFR in lung squamous cell carcinoma and adenocarcinoma and their relationship with cancer tissue type and lymph node metastasis. Methods : The expression of PCNA and EGFR in 44 cases of lung cancer tissues and 16 cases of normal lung tissues were detected by immunohistochemical S-P method. Results: The expression of PCNA and EGFR in lung cancer tissues was significantly higher than that in normal lung tissues. Compared with adenocarcinoma, the expression of PCNA and EGFR was not statistically different (P>0.05). There was no significant difference in the expression of PCNA and EGFR between lymph node metastasis-positive cancer tissues and lymph node metastasis-negative cancer tissues (P>0.05). Conclusion : PCNA and EGFR are involved in the occurrence and development of lung cancer, and there is a certain correlation in the expression of lung cancer. Both had nothing to do with squamous cell carcinoma and adenocarcinoma classification, and had nothing to do with lymph node metastasis.