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目的：探讨血清总胆汁酸对乙型肝炎患者肝功能判定的临床意义。方法：检测58例A（n＝21）、B（n＝21）、C（n＝16）不同肝功能分级（按child－pugh分）的乙肝患者及20例正常对照组的血清TBA、TBIL及ALT。结果：乙肝患者TBA水平明显高于正常对照组，且随着肝功能分级的增加（A→B→C级）而显著升高（P＜0．01）；血清TBA水平与TBIL、ALT水平呈显著正相关（r＝0．54和r＝0．59）；TBA＜71．3μmol／L可作为肝功能代偿良好的判定点。结论：血清TBA的检测对判定乙型病毒性肝炎肝实质细胞的损害及肝功能的代偿状态具有重要临床意义。
Objective: To investigate the clinical significance of serum total bile acid in judging liver function in patients with hepatitis B Methods: Serum TBA and TBIL were detected in 58 cases of hepatitis B patients with A (n = 21), B (n = 21) and C (n = 16) liver function grading by child-pugh and 20 normal controls And ALT. Results: The level of TBA in patients with hepatitis B was significantly higher than that in controls (P <0.01), and the levels of TBA, TBIL and ALT in patients with hepatitis B were significantly higher than those in controls (R = 0.54 and r = 0.59); TBA <71.3μmol / L could be used as a good decision point of liver function compensation. Conclusion: The detection of serum TBA has important clinical significance in judging the damage of hepatic parenchymal cells and the compensatory state of hepatic function of hepatitis B virus.