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目的观察艾可清颗粒联合高效抗反转录病毒治疗(HAART),对艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)中,免疫重建不良者CD4~+T淋巴细胞(简称CD4细胞)水平的影响。方法符合纳入标准的病人70例,随机分为治疗组和对照组各35例,治疗组在HAART基础上给予中药艾可清颗粒,对照组只进行HAART,评价5个时点(治疗前和治疗3、6、9、12个月)2组CD4细胞计数变化和免疫重建有效率。结果治疗9个月和12个月时,治疗组CD4细胞计数与对照组相比均显著升高(t=-2.664,P=0.011;t=-2.468,P=0.016),2个时点治疗组免疫重建有效率分别为58.06%(18/31)和48.39%(15/31),均高于对照组的31.25%(10/32)和21.88%(7/32),差异均有统计学意义(Z=-2.349,P=0.019;Z=-2.045,P=0.041)。结论艾可清颗粒联合HAART可一定程度提高免疫重建不良HIV/AIDS病人的CD4细胞计数,并且提高免疫重建有效率。
Objective To observe the protective effect of Ai Ke Qing Granules combined with highly effective antiretroviral therapy (HAART) on HIV / AIDS patients (HIV / AIDS patients), immunocompromised patients with CD4 ~ + T lymphocytes (CD4 cells for short) the impact of the level. Methods Seventy patients, who met the inclusion criteria, were randomly divided into treatment group (n = 35) and control group (n = 35). The treatment group was treated with Ai Ke Qing Granule on the basis of HAART, while the control group only HAART. 3, 6, 9 and 12 months), the change of CD4 cell count and the efficiency of immune reconstruction in 2 groups. Results At 9 and 12 months of treatment, CD4 cell count in treatment group was significantly higher than that in control group (t = -2.664, P = 0.011; t = -2.468, P = 0.016) The effective rates of group immunosuppression were 58.06% (18/31) and 48.39% (15/31), respectively, which were higher than that of the control group (31.25%, 10/32) and 21.88% (7/32) Significance (Z = -2.349, P = 0.019; Z = -2.045, P = 0.041). Conclusions Aiqijing granule combined with HAART can improve the CD4 cell count of immunosuppressed dysplastic HIV / AIDS patients to a certain extent and improve the efficiency of immune reconstitution.