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[目的]观察幼儿便血在结肠镜检中联合使用小剂量镇静、催眠、解痉剂的效果。[方法]2.4~7.2岁便血患儿52例,随机分为试验组34例,对照组18例。用相同的术前准备方法,试验组于术前肌内注射异丙嗪和山莨菪碱,静脉推注咪达唑仑,待患儿安静睡眠后行结肠镜检查。在检查前、中、后监测心率及血氧饱和度,观察躁动、腹痛、恶心、呕吐,记录操作时间和成功率。对照组仅于术前肌注山莨菪碱,其他方法同试验组。[结果]试验组结肠镜检查成功率100%,躁动、腹痛、恶心、呕吐、心率及血氧饱和度,术前后无明显变化,与对照组比较差异有统计学意义(P<0.01)。[结论]小剂量咪达唑仑、异丙嗪及山莨菪碱应用于幼儿结肠镜检查术,安全有效,无不良反应及并发症发生。
[Objective] To observe the effects of low dose sedative, hypnotic and antispasmodic agents combined with colonoscopy in preschool blood in children. [Method] Fifty-two children with blood in the stool from 2.4 to 7.2 years old were randomly divided into experimental group (n = 34) and control group (n = 18). Using the same method of preoperative preparation, the experimental group was given intramuscular injection of promethazine and anisodamine intramuscularly, and midazolam intravenously. The patients underwent a colonoscopy after their sleep was quiet. Before, during and after the monitoring of heart rate and oxygen saturation, observed agitation, abdominal pain, nausea, vomiting, recording operation time and success rate. The control group was treated with anisodamine intramuscularly only in the preoperative and other methods were the same as the experimental group. [Results] The success rate of colonoscopy in test group was 100%. Restlessness, abdominal pain, nausea, vomiting, heart rate and oxygen saturation had no significant changes before and after operation. There was significant difference between the two groups (P <0.01). [Conclusion] Low dose midazolam, promethazine and anisodamine are safe and effective for early childhood colonoscopy. No adverse reactions and complications occurred.