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对盐酸维拉帕米缓释片(VR·HCl-SRT)的体外溶出速率进行了研究,HPLC法测定了8名健康受试者口服单剂量及多剂量时的稳态血药浓度,并以Knoll公司Isoptin-SRT及市售普通片为对照,实验数据按单室模型采用AST 360型计算机和非线性最小二乘法模型嵌合程序进行迭代处理,求得药动学参数。结果表明:VR·HCl-SRT达峰时间较Isoptin-SRT短,而维持体内有效血浓时间长,相对生物利用度为112.9%,体内外显著相关。理论值与实测值基本相符。
The in vitro dissolution rate of verapamil hydrochloride sustained-release tablets (VR · HCl-SRT) was studied. The steady-state plasma concentrations of 8 healthy volunteers were determined by oral administration of single and multiple doses of Knopys Isoptin-SRT and commercial common tablets as a control, the experimental data by single-chamber model using AST 360 computer and nonlinear least squares model fitting process iterative process, obtained pharmacokinetic parameters. The results showed that the peak time of VR · HCl-SRT was shorter than that of Isoptin-SRT, while the effective blood concentration was maintained for a long time in vivo. The relative bioavailability was 112.9%, which was significantly correlated in vivo and in vitro. The theoretical value and the measured value basically match.