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目的评价氟康唑早期经验性治疗ICU真菌感染的临床效果。方法回顾性分析解放军第二六一医院2010年1月~2012年12月收治的真菌感染患者67例的临床资料,将患者分为对照组和观察组。对照组患者在临床证据证明为真菌感染后给予氟康唑行抗真菌治疗,观察组患者在真菌感染早期即行抗真菌治疗。两组患者治疗均应用氟康唑,时间为14 d,治疗过程中根据患者肾功能情况调整用药剂量。对两组患者治疗的总有效率进行比较。结果对照组、观察组的抗真菌感染总有效率分别为59.38%、91.43%,差异有统计学意义(P<0.05)。结论应用氟康唑对ICU真菌感染患者进行早期经验性治疗有助于提高抗真菌感染治疗有效率,值得临床推广。
Objective To evaluate the clinical efficacy of early empirical fluconazole in the treatment of ICU fungal infections. Methods The clinical data of 67 cases of fungal infections admitted to the 216th Hospital of PLA from January 2010 to December 2012 were retrospectively analyzed. Patients were divided into control group and observation group. Patients in the control group received antifungal therapy with fluconazole after clinical evidence of fungal infection. Patients in the observation group received antifungal therapy immediately prior to the fungal infection. Fluconazole was used in both groups for 14 days, and the dosage of the drug was adjusted according to the renal function of the patients during the treatment. The total effective rate of treatment for both groups was compared. Results The total effective rates of antifungal infections in the control group and observation group were 59.38% and 91.43%, respectively, with statistical significance (P <0.05). Conclusion The early empirical treatment of patients with ICU fungal infection with fluconazole will help to improve the anti-fungal infection treatment efficiency, worthy of clinical promotion.