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目的 探讨急性缺血性脑血管病 (AICVD)患者血清可溶性细胞间粘附分子 -1(sICAM -1)水平及其临床意义。方法 采用双抗体夹心酶联免疫吸附法 (ELISA)测定 67例AICVD患者、45例AICVD易患者及 40名正常对照者血清中sICAM -1水平。结果 AICVD组血清sICAM -1水平明显高于易患因素组 (P <0 0 5 ) ,易患因素组又高于正常对照组 (P <0 0 5 )。结论 sICAM -1水平与急性缺血性脑血管病的发生发展有关 ,血清sICAM -1水平可作为急性缺血性脑血管病监测的参考指标
Objective To investigate the serum soluble intercellular adhesion molecule-1 (sICAM-1) levels in patients with acute ischemic cerebrovascular disease (AICVD) and its clinical significance. Methods Serum levels of sICAM-1 in 67 patients with AICVD, 45 patients with AICVD and 40 normal controls were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results The level of serum sICAM - 1 in AICVD group was significantly higher than that in susceptible group (P <0.05), and was higher in susceptible group than in normal control group (P <0.05). Conclusion The level of sICAM-1 is related to the occurrence and development of acute ischemic cerebrovascular disease. Serum sICAM-1 level can be used as a reference indicator for the monitoring of acute ischemic cerebrovascular disease