论文部分内容阅读
目的探讨血浆D-二聚体、血管性血友病因子(v WF)、纤维蛋白原检测在恶性血液病诊断中的临床价值。方法选取桃源县第三人民医院2014年7月—2015年7月收治的恶性血液病患者120例为观察组,并选择同期本院健康体检者120例为对照组,比较两组血浆D-二聚体、v WF、纤维蛋白原水平。按恶性血液病种类将观察组分为A、B、C 3个亚组,比较3组患者血浆D-二聚体、v WF、纤维蛋白原水平。治疗1年后根据治疗效果将观察组患者分为存活组和死亡组,比较两组血浆D-二聚体、v WF和纤维蛋白原水平。结果观察组患者D-二聚体、v WF和纤维蛋白原水平均高于对照组,差异有统计学意义(P<0.05)。观察组各亚组间D-二聚体、v WF和纤维蛋白原水平比较,差异有统计学意义(P<0.05)。存活组患者的D-二聚体、v WF和纤维蛋白水平低于死亡组,差异有统计学意义(P<0.05)。结论血浆D-二聚体、v WF、纤维蛋白原可作为辅助诊断恶性血液病的早期参考指标,与恶性血液病的预后有一定相关性。
Objective To investigate the clinical value of plasma D-dimer, von Willebrand factor (v WF) and fibrinogen in the diagnosis of hematologic malignancies. Methods 120 cases of hematologic malignancies admitted to the Third People’s Hospital of Taoyuan County from July 2014 to July 2015 were selected as the observation group and 120 healthy subjects were selected as the control group in the same period. VWF, fibrinogen levels. According to the types of hematologic malignancies, the observation group was divided into A, B and C subgroups, and the plasma D-dimer, v WF and fibrinogen levels were compared among the three groups. One year after treatment, the patients in the observation group were divided into survival group and death group according to the therapeutic effect. Plasma D-dimer, vWF and fibrinogen levels were compared between the two groups. Results The levels of D-dimer, vWF and fibrinogen in the observation group were significantly higher than those in the control group (P <0.05). There was significant difference in the levels of D-dimer, v WF and fibrinogen in each subgroup of observation group (P <0.05). D-dimer, v WF and fibrin levels in survival group were lower than those in death group, with significant difference (P <0.05). Conclusions Plasma D-dimer, v WF, fibrinogen can be used as early reference indicators in the diagnosis of hematologic malignancies, and have some correlation with the prognosis of hematologic malignancies.