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为探讨小儿结节性胃炎的病理改变与HP的CagA、VacA的关系。对胃镜检查发现胃粘膜呈小颗粒状或结节状改变的30例患儿作快速尿素酶试验、切片吉姆氏染色作HP及病理组织学检查，同时采血2ml作血清HP的CagA、VacA免疫印迹检测并设对照。结果:结节性胃炎多由HP感染所致，感染率为80%，与感染产毒素的HP菌株有关，且以活动性胃炎为主，在所感染的HP菌株中CagA抗体全部为阳性，在CagA~+、vacA~+菌株中病变的炎症反应较CagA~+、VacA一菌株严重，HP感染后的结节性胃炎全部有淋巴细胞浸润。提示小儿结节性胃炎应考虑根除疗法。
To investigate the pathological changes in children with nodular gastritis and HP CagA, VacA relationship. Gastroscopy found gastric mucosa was small granular or nodular changes in 30 patients for rapid urease test, slicing Jim’s stain for HP and histopathological examination, while blood 2ml for serum HP CagA, VacA Western blot Test and set the control. Results: Most of nodular gastritis was caused by HP infection, the infection rate was 80%, which was related to HP strain producing toxin and active gastritis. CagA antibody was positive in all infected HP strains. CagA ~ +, vacA ~ + strains in the inflammatory response than CagA ~ +, VacA serious strain, HP infection of all nodular gastritis with lymphocyte infiltration. Tip pediatric gastritis should consider eradication therapy.