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肾源性系统性纤维化(NSF)是一种仅发生于肾功能不全患者的少见但严重的后天性获得性、系统性疾病,以广泛的组织纤维化为特征。其病因尚未明确。最近有报道指出使用含钆造影剂和NSF的发病有较强的相关性。本文就NSF的流行病学、临床病史和病理学特征、含钆造影剂在NSF发病中所扮演的角色,以及放射科医师在这个问题上应该注意的事项做一综述。
Renal Systemic Fibrosis (NSF) is a rare but serious acquired acquired systemic disease that occurs only in patients with renal insufficiency and is characterized by extensive tissue fibrosis. The etiology is not yet clear. Recently it has been reported that there is a strong correlation between the use of gadolinium-containing contrast agents and the incidence of NSF. This article reviews the epidemiology, clinical history and pathological features of NSF, the role of gadolinium-containing contrast medium in the pathogenesis of NSF, and the issues that radiologists should pay attention to in this issue.