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目的探讨ⅡA分泌型磷脂酶A2(secretory phospholipase A2 groupⅡA,ⅡAsPLA2)、三叶因子3(trefoil factor 3,TFF3)在胃癌及癌前病变中的表达及其意义。方法采用免疫组化法检测二者在90例胃癌、80例胃黏膜异型增生及30例正常胃黏膜组织中的表达。结果ⅡA sPLA2、TFF3在轻度、中度+重度异型增生胃黏膜、早期胃癌、进展期胃癌各组中的表达均高于正常胃黏膜组,它们之间存在统计学意义(P<0.05)。结论ⅡA sPLA2表达降低可能与胃癌的侵袭性以及转移间存在着某种相关性,其低表达是胃癌预后评估的一个潜在指标。TFF3可能是胃黏膜恶性变过程中的早期分子事件,在胃黏膜恶性变及其以后的恶性演进过程中起作用,对胃癌早期诊断、治疗以及预测胃癌发生癌周组织转移可能具有重要的提示作用,二者在胃癌的发生、发展及演变过程中起着协同的作用,并对胃癌的预后存在一定的指导作用。
Objective To investigate the expression and significance of secretory phospholipase A2 group Ⅱ A (ⅡAsPLA2) and trefoil factor 3 (TFF3) in gastric cancer and precancerous lesions. Methods Immunohistochemistry was used to detect the expression of the two in 90 cases of gastric cancer, 80 cases of gastric dysplasia and 30 cases of normal gastric mucosa. Results The expressions of ⅡA sPLA2 and TFF3 in mild, moderate and severe dysplastic gastric mucosa, early gastric cancer and advanced gastric cancer were significantly higher than those in normal gastric mucosa (P <0.05). Conclusion The decreased expression of Ⅱ sPLA2 may be related to the invasiveness and metastasis of gastric cancer. The low expression of Ⅱ s sPLA2 may be a potential indicator of the prognosis of gastric cancer. TFF3 may be an early molecular event in the process of gastric mucosal malignant transformation and plays a role in the malignant transformation of gastric mucosa and its subsequent malignant progression. TFF3 may be an important indicator for the early diagnosis and treatment of gastric cancer and the prediction of the carcinogenesis of gastric cancer , Both of which play a synergistic role in the occurrence, development and evolution of gastric cancer, and have a guiding role in the prognosis of gastric cancer.