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目的研究老年稳定性心绞痛(SAP)合并T2DM患者踝肱指数(ABI)异常情况及临床意义。方法选择SAP合并T2DM(SAP+T2DM组)老年患者50例,SAP(SAP组)老年患者48例,T2DM(T2DM组)老年患者35例,测定ABI、高敏C反应蛋白(hsC-RP)、髓过氧化物酶(MPO)水平和血管内皮功能。结果 SAP+T2DM组ABI值与SAP、T2DM组比较差异有统计学意义[(0.46±0.19)vs(0.96±0.17)vs(0.97±0.12),P<0.05];SAP+T2DM组与SAP、T2DM组MPO、hsC-RP水平比较差异有统计学意义[(274.3±91.4)vs(109.7±28.7)vs(107.4±18.6)mmol/L;(7.93±2.8)vs(1.53±0.5)vs(1.18±0.6)mg/L,P<0.05];SAP+T2DM组与SAP、T2DM组肱动脉内皮依赖性舒张功能比较差异有统计学意义[(3.89±2.99)%vs(7.85±1.94)%vs(7.90±4.36)%,P<0.05]。结论 ABI降低对评价动脉功能损害及识别高危患者有重要的临床意义。
Objective To investigate the abnormality of ankle brachial index (ABI) in elderly patients with stable angina pectoris (SAP) and T2DM and its clinical significance. Methods Fifty elderly patients with SAP combined with T2DM (SAP + T2DM group), 48 elderly patients with SAP (SAP group) and 35 elderly patients with T2DM (T2DM group) were enrolled in this study. ABI, hsC-RP, Peroxidase (MPO) levels and vascular endothelial function. Results The ABI of SAP + T2DM group was significantly different from that of SAP and T2DM groups (0.46 ± 0.19 vs 0.96 ± 0.17 vs 0.97 ± 0.12, P <0.05) There were significant differences in the levels of MPO and hsC-RP between the two groups (274.3 ± 91.4 vs 109.7 ± 28.7 vs 107.4 ± 18.6 mmol / L vs 7.93 ± 2.8 vs 1.53 ± 0.5 vs 1.18 ± (3.89 ± 2.99)% vs (7.85 ± 1.94)% vs (7.90 ± 0.66) mg / L, P <0.05]. The endothelium-dependent vasodilation of brachial artery in SAP + T2DM group was significantly lower than that in SAP group ± 4.36)%, P <0.05]. Conclusions The decrease of ABI has important clinical value in evaluating arterial dysfunction and identifying high-risk patients.