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目的 探讨经母亲肌注乙肝免疫球蛋白(HBIG)阻断乙型肝炎病毒母婴传播的效果。方法 对A组100名HBsAg(+)的孕妇于24、28、32、36周肌注100U乙肝免疫球蛋白,B组96名HBsAg(+)的孕妇未肌乙肝免疫球蛋白,新生儿出生时抽脐血检测HBsAg和HBV DNA,并联合免疫注射HBIG、乙型肝炎疫苗。结果 A组新生儿脐血HBsAg和HBV DNA阳性率明显低于B组,与B组相比具有显著差异。结论 肌注乙肝免疫球蛋白能有效阻断乙型肝炎母婴传播。
Objective To investigate the effect of mother’s intramuscular injection of hepatitis B immunoglobulin (HBIG) on the mother-to-child transmission of hepatitis B virus. Methods One hundred 100 HBsAg (+) pregnant women in group A were intramuscularly injected with 100U hepatitis B immunoglobulin at 24, 28, 32 and 36 weeks. 96 pregnant women with HBsAg (+) in group B did not have muscle hepatitis B immunoglobulin. Umbilical cord blood test for HBsAg and HBV DNA, and combined immunization with HBIG, hepatitis B vaccine. Results The positive rate of HBsAg and HBV DNA in neonatal cord blood of group A was significantly lower than that of group B, which was significantly different from that of group B. Conclusion Intramuscular injection of hepatitis B immunoglobulin can effectively block the transmission of hepatitis B virus.