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苯甲异恶唑青霉素(OX)、邻氯苯甲异(?)唑青霉素(CX)、双氯苯甲异(?)唑青霉素(DX)和2,6-氟氯苯甲异(?)唑青霉素(FX)是目前临床用于化疗的半合成异(?)唑基青霉素的同系物(如图1)。已知这些青霉素对革蓝氏阳性细菌,包括耐青霉素G的葡萄球菌具有抑制作用。这些药物对酸稳定,适量口服可经胃肠道有效吸收。除了这些药物的化学和生理化学特性而外,迄今已积累了关于它们的生物药物特性的资料,尤其是药代动力学行为的资料。
(OX), o-chlorobenzamide (CX), dicloxacin (DX) and 2,6- Xanthocecium (FX) is currently used clinically for the chemotherapy of semisynthetic iso-azole penicillin homolog (Figure 1). These penicillins are known to have an inhibitory effect on gram-positive bacteria, including penicillin-resistant staphylococci. These drugs are stable to the acid, the amount of oral absorption by the gastrointestinal tract effectively. In addition to the chemical and physico-chemical properties of these drugs, to date, information has been accumulated on their biopharmaceutical properties, especially on pharmacokinetic behavior.