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目的 探讨单纯疱疹病毒性脑炎 (HSE)患者神经系统主要临床症状与脑电图(EEG)异常程度、异常范围的相关性。方法 回顾性统计、对比、分析 31例 HSE患者住院早期、用无环鸟苷 (ACV)治疗 4～ 8天和出院前三个病程阶段的神经系统主要临床症状和疗效状况 ,及与其相对应的 EEG异常程度和异常范围的变化。结果 HSE患者神经系统主要临床症状为精神症状、癫痫、意识障碍、记忆力下降 ;在前两个病程阶段 ,四种症状的 EEG异常程度和异常范围的排序基本相同 ,并与病情呈同步变化 ;经 ACV治疗后 ,EEG异常范围缩小的幅度比异常程度减轻的幅度小。结论 EEG异常范围和异常程度的变化可同步反映 HSE患者神经系统主要症状的变化 ,当异常范围的变化幅度与异常程度变化幅度有一定差距时 ,可能说明患者正由急性期向稳定——恢复期转变。
Objective To investigate the correlation between the major clinical symptoms of nervous system and the abnormality and abnormal range of EEG in patients with herpes simplex virus encephalitis (HSE). Methods The clinical data of 31 patients with HSE who were hospitalized early, acyclovir (ACV) for 4 ~ 8 days and before discharge were analyzed retrospectively. The main clinical symptoms and therapeutic effects of the nervous system were analyzed, EEG abnormalities and abnormal changes in the range. Results The main clinical symptoms of nervous system in HSE patients were mental symptoms, epilepsy, disturbance of consciousness and memory loss. In the first two stages of disease, the order of abnormalities and abnormalities of four kinds of symptoms were basically the same and changed synchronously with the condition. After ACV treatment, the scope of EEG abnormalities narrowed less than the extent of abnormalities. Conclusions The changes of EEG abnormalities and abnormalities can reflect the changes of the main symptoms of nervous system in patients with HSE simultaneously. When there is a certain difference between the range of abnormalities and the extent of abnormal changes, it may indicate that the patients are changing from acute phase to stable-convalescence phase change.