代谢综合征(MS)与冠心病、高血压、脑卒中、痛风、非酒精性脂肪肝(NASH)等疾病群密切相关,胰岛素抵抗(IR)是MS的中心环节。超长链脂肪酸延伸酶6(ELOVL6)是ELOVL家族的第6个成员,广泛分布于具有内质网结构的组织细胞中,主要参与C12-16饱和与不饱和脂肪酸的合成,ELOVL6可通过调节细胞内脂质成分,从而影响胰岛素受体磷酸化,调节部分炎性体,炎性因子活性和炎性信号通路蛋白磷酸化水平,在机体能量代谢平衡,IR、NASH及动脉粥样硬化等疾病的发病中发挥着重要作用。 Metabolic syndrome (MS) and coronary heart disease, hypertension, stroke, gout, non-alcoholic fatty liver disease (NASH) and other diseases are closely related to insulin resistance (IR) is the center of MS. Ultra-long chain fatty acid elongase 6 (ELOVL6) is the sixth member of the ELOVL family, widely distributed in endoplasmic reticulum tissue cells, mainly involved in the synthesis of C12-16 saturated and unsaturated fatty acids, ELOVL6 by regulating cells Lipid components, which affect the insulin receptor phosphorylation, regulate some inflammatory, inflammatory cytokines and inflammatory signaling pathway phosphorylation level, the balance of energy metabolism, IR, NASH and atherosclerosis and other diseases In the pathogenesis plays an important role.