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目的:探究骨化三醇联合补气口服液对慢性肾功能衰竭患者血清瘦素及睾酮水平的影响。方法:选取我院诊治慢性肾功能衰竭患者116例为研究对象,根据随机数字对照表分为对照组(58例)与试验组(58例)。两组患者均常规给予血管紧张素酶抑制剂或β受体阻滞剂,对照组给予口服骨化三醇胶丸,试验组在对照组的基础上联合给予补气口服液。治疗结束后,比较两组患者肾功能指标、血清瘦素及睾酮水平、营养生化指标。结果:治疗结束后,两组患者血清肌酐(Cr)、血尿素氮(BUN)及瘦素水平均较治疗前显著降低(P<0.05),睾酮、血钙水平较治疗前升高(P<0.05),血磷水平降低(P<0.05)。与对照组相比,试验组血Cr、BUN及瘦素水平较低(P<0.05),而血清睾酮、血钙水平较高,血磷水平较低(P<0.05)。结论:骨化三醇联合补气口服液能够更有效改善慢性肾功能衰竭患者的肾功能,纠正患者体内电解质紊乱,改善患者食欲不振营养不良症状,推测其与降低血清瘦素水平及升高睾酮水平有关。
Objective: To investigate the effects of calcitriol combined with qi oral liquid on serum leptin and testosterone levels in patients with chronic renal failure. Methods: A total of 116 patients with chronic renal failure who were diagnosed and treated in our hospital were enrolled in this study. According to random number table, 58 patients were divided into control group and 58 patients in experimental group. Both groups were given conventional angiotensin inhibitor or β blockers, the control group given oral calcitriol capsules, the experimental group in the control group based on the combination of Buqi oral solution. After treatment, the renal function, serum leptin and testosterone levels, nutritional biochemical indexes were compared between the two groups. Results: Serum creatinine (Cr), blood urea nitrogen (BUN) and leptin levels were significantly lower in both groups after treatment than those before treatment (P <0.05), while testosterone and serum calcium levels were significantly higher than those before treatment (P < 0.05), serum phosphorus decreased (P <0.05). Compared with the control group, the levels of serum Cr, BUN and leptin in the experimental group were lower (P <0.05), while serum testosterone and serum calcium levels were higher and the serum phosphorus level was lower (P <0.05). Conclusion: calcitriol combined with qi oral liquid can more effectively improve renal function in patients with chronic renal failure, to correct electrolyte imbalance in patients with poor appetite to improve symptoms of malnutrition, presumably with lower serum leptin levels and elevated testosterone Horizontal related.