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[目的]研究骨嗜酸性肉芽肿患者的核素全身骨显像表现特征,探讨骨显像在诊断和疗效观察中的应用价值.[方法]回顾性分析49例经病理证实的骨嗜酸性肉芽肿患者的核素全身骨显像表现特征,并与X 线摄片结果对比观察,11例患者在治疗后复查全身骨显像对疗效及病情进展进行动态监测.[结果]49例患者中,骨显像发现单发病灶27例(55.1%),多发病灶22例(44.9%),骨显像共发现病灶132处.在22例多发病灶患者中,骨显像发现105处病灶,其中32例 X 线检查未发现异常;而 X 线共发现病灶78处,其中5处骨显像表现为阴性.两者相比,骨显像较 X 线检查能够发现更多的病灶,差异具有统计学意义(χ2=23.686,P <0.01).11例患者治疗后复查了骨显像,8例单发病灶患者手术效果良好,1例单发及 2例多发病灶患者出现新的病灶.[结论]骨嗜酸性肉芽肿在核素全身骨显像上具有一定特征性表现,骨显像对多发病灶的探测能力优于 X 线,可作为治疗过程中疗效监测的常规手段.“,”Objective] To study the features of eosinophilic granuloma of bone(EGB) on radionuclide bone scan and explore the value of bone scan in the diagnosis and treatment monitoring .[Methods] The features of whole body bone scan in 49 EGB patients confirmed pathology were analyzed retrospectively .The results were contrastively analyzed with X‐ray .Whole body bone scan of 11 patients were performed again after treatment so as to monitor the efficacy and progression dynamically .[Results] In 49 patients ,bone scan showed that 27 patients(55 .1% ) had single lesion and 22 patients(44 .9% ) had multiple lesions .Bone scan detected 132 le‐sions .In 22 patients with multiple lesions ,bone scan detected 105 lesions ,in which 32 lesions were not detec‐ted by X‐ray .On the other hand ,X‐ray examination detected 78 lesions in these 22 patients ,in which 5 lesions had no abnormality on bone scan .Bone scan could discover more lesions than X‐ray examination ,and there was significant difference(χ2 = 23 .686 ,P < 0 .01) .Eleven patients underwent follow‐up bone scan .Eight pa‐tients with single lesion showed fine result after surgery ,and another one with single lesion and 2 patients with multiple lesions showed new focus presence .[Conclusion] Eosinophilic granuloma of bone has a certain char‐acteristic findings on radionuclide bone scan .The detecting ability of bone scan is better than X‐ray for multi‐ple lesions .Bone scan may be act as a routine tool for the efficacy monitoring during treatment .