论文部分内容阅读
目的观察加巴喷丁胶囊联合氨酚曲马多片治疗带状疱疹后遗神经痛(PHN)的临床效果。方法将医院2014年3月-2017年3月疼痛科收治的PHN患者60例,随机分为观察组和对照组,每组30例。对照组单纯给予加巴喷丁治疗,观察组患者在对照组基础上联合使用氨酚曲马多片治疗。治疗结束后,评价2组患者的治疗效果,随访2 d,采用视觉疼痛评分(VAS)对2组患者治疗前后疼痛改善情况进行比较。结果观察组治疗总有效率为83.33%高于对照组的70.00%,差异有统计学意义(P<0.05)。随访2 d 2组患者治疗后VAS评分较治疗前均有显著改善,且观察组显著优于对照组,差异有统计学意义(P<0.05)。治疗过程中,观察组出现眩晕1例、恶心1例;对照组出现疲劳1例,头痛1例,2组不良反应发生率均为6.67%,2组比较无明显差异(P>0.05)。结论加巴喷丁胶囊联合氨酚曲马多片治疗PHN的效果显著优于单纯使用加巴喷丁,不但能显著改善患者症状,更能缓解疼痛,有助于预后,值得推广。
Objective To observe the clinical effect of gabapentin capsules combined with paracetamol tramadol tablets in the treatment of postherpetic neuralgia (PHN). Methods Sixty patients with PHN who were admitted to the department of pain from March 2014 to March 2017 in our hospital were randomly divided into observation group and control group with 30 cases in each group. The control group was treated with gabapentin alone. The patients in the observation group were treated with paracetamol and tramadol on the basis of the control group. After the treatment, the therapeutic effects of the two groups were evaluated. After 2 days of follow-up, visual acuity scores (VAS) were compared between the two groups before and after treatment to improve the pain. Results The total effective rate of observation group was 83.33%, which was higher than that of control group (70.00%), the difference was statistically significant (P <0.05). After treatment, the VAS scores of patients in 2 days and 2 days after treatment were significantly improved, and the observation group was significantly better than the control group, the difference was statistically significant (P <0.05). In the course of treatment, 1 case of dizziness and 1 case of nausea occurred in the observation group; 1 case of fatigue and 1 case of headache in the control group. The incidence of adverse reactions in both groups was 6.67%. There was no significant difference between the two groups (P> 0.05). Conclusion The effect of gabapentin capsule combined with trastuzumab in the treatment of PHN is significantly better than that of gabapentin alone. It not only can significantly improve the symptoms of patients, but also can relieve the pain and promote the prognosis, which is worth promoting.