测定ＩＮＳ患儿Ｔ、Ｂ细胞增殖功能，血清ＩｇＧ亚类，ＰＷＭ诱导的体外ＩｇＧ类产生及ＢｃＧＦ、ＢｃＤＦ、ＩＬ－６活性。结果显示ＩＮＳ发作期儿童Ｔ、Ｂ细胞增殖功能低下；血清及体外产生ＩｇＧ１、ＩｇＧ２及ＩｇＧ４低下，ＩｇＧ３和ＩｓＭ正常；ＢＣＧＦ活性降低与Ｂ细胞增殖功能低下呈直线正相关；ＢＣＤＦ及ＩＬ－６活性降低与体外ＩｇＧ产生低下呈直线正相关。结果提示ＩＮＳ可能存在Ｉｇ类别转换障碍致低ＩｇＧ血症。Ｔ细胞及其分泌的淋巴因子异常可能在其中起重要作用 The proliferation of T and B cells, serum IgG subclasses, PWM-induced in vitro IgG production and BcGF, BcDF and IL-6 activity in children with INS were measured. The results showed that the proliferation of T and B cells in children with INS during INS attack was poor, IgG1, IgG2 and IgG4 were low in serum and in vitro, IgG3 and IsM were normal, but the decrease of BCGF activity was positively correlated with the low proliferation of B cells. The activity of BCDF and IL-6 There was a linear positive correlation between reduction and low IgG production in vitro. The results suggest that INS may have Ig grade dyscrasia-induced hypo-IgGmia. T cells and their abnormal secretion of lymphokines may play an important role