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目的探讨血浆D 二聚体在急性脑梗死 (ACI)发病过程中的变化与预后的关系。方法采用Latex半定量法动态检测 93例患者及 2 0例正常对照者血浆D 二聚体变化 ,分析其与梗死体积大小、病情程度及预后的相关性。结果ACI患者血浆D 二聚体水平与病情严重程度及预后关系密切 ,其中大体积梗死组血浆D 二聚体升高水平越高 ,持续时间越长 ;神经功能缺损程度越重 ,其预后也越差 ,与中、小体积梗死组比较 ,差异非常显著 (P <0 .0 1)。结论ACI患者血浆D 二聚体水平可作为判断病情及预后的客观指标。
Objective To investigate the relationship between the changes of plasma D-dimer and the prognosis in the pathogenesis of acute cerebral infarction (ACI). Methods Latex semi-quantitative method was used to detect the changes of plasma D-dimer in 93 patients and 20 normal controls. The correlation between the D-dimer and infarct volume, severity of disease and prognosis were analyzed. Results The level of plasma D-dimer in ACI patients was closely related to the severity and prognosis of patients with ACI. The higher plasma D dimer level and the longer duration of plasma ACI in ACI patients, the greater the severity of neurological deficits and the worse prognosis Difference, compared with medium and small volume infarction group, the difference was significant (P <0.01). Conclusion Plasma D-dimer level in ACI patients can be used as an objective index to judge the condition and prognosis.