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目的观察中西医结合对恶性肿瘤骨转移患者疼痛的干预效果。方法将136例恶性肿瘤骨转移患者随机分为治疗组69例和对照组67例,对照组给予唑来膦酸静脉滴注,治疗组在对照组治疗方法的基础上加用中医疗法治疗。7 d为1个疗程,连续治疗3个疗程。治疗结束后1周比较2组患者的临床疗效、不良反应发生情况,治疗结束3月后比较2组的生活质量评分。结果治疗组总有效率为79.71%,对照组为56.72%,2组比较差异有统计意义(P<0.05);治疗组发生便秘及腹泻的次数明显少于对照组,2组比较差异有统计意义(P<0.05);2组患者治疗结束3月后生活质量评分均较同组治疗前显著降低,差异有统计意义(P<0.05),且治疗组降低幅度更为明显,与对照组比较,差异有统计意义(P<0.05)。结论中西医结合治疗不仅可以缓解恶性肿瘤骨转移患者的疼痛,减少药物产生的不良反应,而且可提高患者的生活质量,值得临床推广。
Objective To observe the effect of integrated traditional Chinese and western medicine on the pain of patients with malignant tumor bone metastasis. Methods Thirty-six patients with malignant tumor bone metastasis were randomly divided into treatment group (n = 69) and control group (n = 67). The control group was given zoledronic acid intravenously. The treatment group was treated with Chinese medicine treatment based on the control group. 7 d for a course of treatment, continuous treatment of 3 courses. One week after the treatment, the clinical efficacy and adverse reactions of the two groups were compared. After three months of treatment, the quality of life scores of the two groups were compared. Results The total effective rate was 79.71% in the treatment group and 56.72% in the control group, the difference between the two groups was statistically significant (P <0.05); the incidence of constipation and diarrhea in the treatment group was significantly less than that in the control group, the difference was statistically significant (P <0.05). The quality of life scores of two groups of patients after 3 months of treatment were significantly lower than those of the same group before treatment (P <0.05), and the reduction rate of the treatment group was more obvious. Compared with the control group, The difference was statistically significant (P <0.05). Conclusion The combination of TCM and WM can not only relieve the pain of patients with malignant bone metastases, reduce the adverse reactions of drugs, but also improve the quality of life of patients, which is worthy of clinical promotion.