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目的 为探讨胃癌和大肠癌细胞HSP90 mRNA表达的特点。方法 利用核酸原位杂交技术, 对79 例胃肠癌组织进行检测。结果 表明HSP90 mRNA在胃癌和大肠癌中的阳性率分别为55 .56% (15/27) 和69. 23% (36/52)。mRNA表达与病理类型、分化程度和有否淋巴结转移有相关性。结论 HSP90 mRNA 在胃肠癌中有较高表达, 检测HSP90 mRNA可以作为提示预后的重要临床指标。
Objective To investigate the expression of HSP90 mRNA in gastric cancer and colorectal cancer cells. Methods 79 cases of gastrointestinal cancer tissues were detected by nucleic acid in situ hybridization. The results showed that the positive rates of HSP90 mRNA in gastric cancer and colorectal cancer were 55.56% (15/27) and 69.23% (36/52) respectively. mRNA expression and pathological type, degree of differentiation and lymph node metastasis are related. Conclusion HSP90 mRNA is highly expressed in gastrointestinal cancer. Detecting HSP90 mRNA may be an important clinical indicator of prognosis.