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一般认为巨噬细胞受刺激下的产物细胞因子(C-ytokines)介导宿主对细菌感染的反应,但对被感染病人,循环中细胞因子浓度的增加并不能恒定地测出.在13名健康男性静脉注入大肠杆菌内毒素(4ng/kg)后和注入生理盐水对照期间,研究人员测定其循环血液中a肿瘤坏死因子恶激素(Cachetin),白细胞间素1β和γ干扰素的浓度和生理、激素的反应。另外8名受试者在接受内毒素或生理盐水前给予异丁苯丙酸. 在整个对照期间,肿瘤坏死因子的血浆浓度一般低于35Pg/ml,但注入内毒素后90—180分钟,平均峰值浓度增至240±70Pg/ml;而注入生理盐水后,肿瘤坏死因子血浆浓度为35±5pg/ml.对90分钟时,宿主的反应与循环中肿瘤坏死因子浓度的增加呈一过
C-ytokines, stimulated by macrophages, are generally thought to mediate host responses to bacterial infections, but the circulating cytokine concentration can not be consistently measured in infected patients.13 of the 13 healthy During intravenous administration of E. coli endotoxin (4 ng / kg) to normal saline controls, the researchers measured the concentration and physiology of circulating tumor necrosis factor alpha, interleukin 1 beta and gamma interferon, Hormonal response. Another eight subjects were given ibuprofen prior to receiving endotoxin or saline, with plasma levels of tumor necrosis factor generally below 35 Pg / ml throughout the control period, but with an average of 90-180 minutes after endotoxin injection The peak plasma concentration increased to 240 ± 70 pg / ml, whereas plasma TNF was 35 ± 5 pg / ml after injection of saline.At 90 minutes, the host response increased with the increase in circulating tumor necrosis factor concentration