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目的：观察IAP化疗加放射治疗晚期非小细胞肺癌的疗效．方法：从1995年5月至1996年4月对30例不能手术的Ⅲb期（23例）和Ⅳ期（7例）非小细胞肺癌病人，先给予IAP方案化疗一疗程，IFO2g第1～4日，ADM40mg第1日，PDD30mg第1～4日。结束后立即给予放疗，放射野包括原发灶和转移灶，原发灶剂量60Gy～70Gy，转移灶据部位不同给予30Gy～70Gy，放疗到40Gy时酌情增加IAP方案化疗一疗程。结果：CR13．33％，PR60％，1年生存率66．66％。毒副作用主要是骨髓抑制，脱发及胃肠道反应。结论；提示IAP化疗加放射治疗晚期非小细胞肺癌有明显的协同杀伤作用，能提高近期疗效、局部控制率和转移灶的消失率，毒副反应经处理后对治疗影响不大。
Objective: To observe the effect of IAP chemotherapy plus radiotherapy for advanced non-small cell lung cancer. METHODS: From May 1995 to April 1996, 30 patients with stage IIIb (23 cases) and stage IV (7 patients) with non-small cell lung cancer who were inoperable were given a course of chemotherapy with IAP regimen. IFO2g 1st to 4th On the first day of ADM 40 mg, PDD 30 mg on the first to fourth days. Immediately after the end of radiotherapy, radiation field, including primary and metastatic lesions, the primary dose of 60Gy ~ 70Gy, metastases according to different parts of the body to give 30Gy ~ 70Gy, radiotherapy to 40Gy appropriate increase IAP regimen chemotherapy a course of treatment. Results: CR 13.33%, PR 60%, 1 year survival rate 66.66%. The toxic side effects are mainly myelosuppression, hair loss and gastrointestinal reactions. Conclusion: It is suggested that IAP chemotherapy combined with radiotherapy has a significant synergistic effect on advanced non-small cell lung cancer, and can improve the short-term efficacy, local control rate, and disappearance rate of metastases. The toxic and side effects have little effect on the treatment.