0　引言　 bcl- 2基因是一种抑制凋亡基因 [1 ] ,通过基因突变或易位 ,使表达增强 .近期研究发现 Bcl- 2蛋白在非淋巴造血系统肿瘤中 ,也有异常表达 .如 :乳腺癌、前列腺癌、肺癌、鼻咽癌、胃癌、神经胶质瘤等 [2 ] ,且认为 Bcl- 2蛋白表达与预后因素有关 [3,4] .目前 ,国内有 0 Introduction The bcl-2 gene is an apoptotic gene that inhibits apoptosis [1] and enhances its expression through gene mutation or translocation. Recent studies have found that Bcl-2 protein is also expressed abnormally in non-lymphocytic hematopoietic tumors. Cancer, prostate cancer, lung cancer, nasopharyngeal cancer, gastric cancer, glioma, etc. [2], and that Bcl-2 protein expression and prognostic factors [3,4]. At present, there are