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肿瘤坏死因子相关凋亡诱导配体(TRAIL)是肿瘤坏死因子超家族成员。TRAIL可与死亡受体DR4、DR5结合,通过触发胱天蛋白酶通路诱导肿瘤细胞凋亡。诱骗受体可与死亡受体竞争结合TRAIL,从而抑制TRAIL的凋亡活性。NF-κB和Bcl-2家族可作为TRAIL敏感性调节的重要靶点。
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily. TRAIL binds to death receptors DR4 and DR5 and induces tumor cell apoptosis by triggering the caspase pathway. Latent receptors can compete with death receptors for binding to TRAIL, thereby inhibiting the apoptotic activity of TRAIL. The NF-κB and Bcl-2 families are important targets for the regulation of TRAIL sensitivity.