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影响药物吸收的因素主要包括机体的生理病理因素以及药物的理化性质和剂型因素,其中,药物穿透生物膜的能力是决定性因素。而优良的药物促吸收剂,可显著改善药物穿透生物膜的能力,从而促进药物吸收,提高药物生物利用度。综述近年来研究报道较多的中药成分类、高分子聚合物类和肽类促吸收剂,并探讨这些促吸收剂的作用机制及其特点。
Factors that affect the absorption of drugs include the body’s physiological and pathological factors as well as the physical and chemical properties of drugs and dosage form factors, of which the drug’s ability to penetrate the biofilm is the decisive factor. The excellent drug absorption enhancers, can significantly improve the ability of drugs to penetrate the biofilm, thereby promoting drug absorption and improve drug bioavailability. In this paper, the traditional Chinese medicine components, macromolecule polymers and peptides absorbers which are reported in recent years are reviewed. The mechanism and characteristics of these absorbers are also discussed.